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If patients are not supported by a strong behavior change program that emphasizes muscle-building exercises and a high-protein diet, they risk losing a significant amount of muscle mass, strength, and bone density, which can result in lowered resting metabolic rate and worsening insulin resistance

How good are they

The data support the development of GLP-1RAs as a promising therapeutic approach for managing the multifaceted clinical manifestations of BBS

It is important to approach this discussion with realistic expectations, given that retatrutide does not currently hold a UK marketing authorisation and is therefore not available as a standard prescription medicine