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Repeated chemotherapy cycles exacerbate MDR, reducing the effectiveness of anticancer agents and impeding treatment success ( Apoptosis or the programmed cell death mechanism holds the key to maintaining cellular homeostasis as well as preventing malignancies ( This review examines recent advances in phytochemical-based nanoparticles that modulate apoptotic pathways to inhibit cancer progression and overcome cancer drug resistance, while also providing insights into ongoing preclinical and clinical studies with emphasis on translational challenges and future opportunities for clinical application

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perstans), subcutaneous tissue (M