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All data were imported into GraphPad Prism version 9.0.1 (GraphPad Software Inc., San Diego, CA)

Inflammatory bowel disease, or IBD, is when there is inflammation, or swelling, in the gastrointestinal (GI) tract and a lifelong immune response

Sample preparation for serum metabolite and untargeted/targeted metabolomic mass spectrometry methods performed in this study were based on previously established protocol (Figure 1