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Health Benefits and Risk Reductions Associated with GLP-1 Medications Health Benefits and Risk Reductions Associated with GLP-1 Medications Kidney and Liver Health Improvements The FLOW trial demonstrated 24% reduction in major kidney disease events among patients with type 2 diabetes and chronic kidney disease ^39

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Additional analyses models (ie, models developed in MEDAL and externally validated in LUNA) showed poorer predictive ability for both the internally validated only models (C-statistics ranging from 0.631 to 0.719) (online supplemental table A5) and the models for external validation (C-statistics 0.610 and 0.677) (online supplemental table A5)