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Reducing oxidative stress is crucial because it influences the activity of tyrosinase

We propose that Lurcher mice suffering from early-onset olivocerebellar degeneration can be considered as a model to study the mechanisms of the components of both cerebellar motor syndrome and CCAS, with the limitation to analogous conditions (e.g., whole cerebellum affection, early loss of Purkinje cells) and of course with all the limitations of murine models of human diseases [254, 255]

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M.2003Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor.1007(April 2003),41504155,0027-8424 122