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Where the research should go next Key open questions include how much endogenous GLP1 increase is needed for sustained weight change, whether combinations of diet, prebiotics, probiotics and nutraceuticals can match injectable outcomes, and the longterm safety of such combinations

CRH exerts its actions through GPCRs (214)

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Some of the side effects we found, like nausea, are well known, and that shows that the method is picking up a real signal, says Sharath Chandra Guntuku, Research Associate Professor in Computer and Information Science (CIS) at Penn Engineering and the studys senior author