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APPETITE REDUCTION: Acts on hypothalamic appetite centres reduces caloric intake and supports weight loss ORAL DELIVERY (SNAC Technology): Semaglutide is a large peptide normally degraded in the GI tract Rybelsus co-formulates semaglutide with SNAC (sodium N-[8-(2-hydroxybenzoyl)amino]caprylate), a permeation enhancer that raises local pH in the stomach to protect semaglutide from pepsin degradation and promotes transcellular absorption across gastric mucosa This is why Rybelsus MUST be taken fasting with 120mL plain water only CLINICAL RESULTS (PIONEER Trials): Rybelsus 7mg: HbA1c reduction ~1.21.4% vs placebo Body weight reduction: ~23 kg vs placebo Non-inferior to liraglutide (injectable GLP-1) in glycaemic control Statistically significant reduction in CV events vs placebo (PIONEER 6) Faq for medicine: 1.When is the dose of Rybelsus increased from 3mg to 7mg

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11 In addition, the NF-B pathway was constitutively activated in the ESCC cell lines