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Although CPT1A and CPT1B exhibit considerable sequence similarity, the sensitivity of these two enzymes to their physiological inhibitor, malonyl-CoA, differs greatly (CPT1A has a ten-fold higher Ki for malonyl-CoA) 39,40
45 A barrier to DPP-4 inhibitor use has been the lack of evidence of CV risk reduction in patients with clinical ASCVD
TBK1: a key regulator and potential treatment target for interferon positive Sjgrens syndrome, systemic lupus erythematosus and systemic sclerosis
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