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Younger patients and those with untreated depression appear at slightly elevated risk, though absolute numbers remain low

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So, one of the adaptations that someone with this impairment has to try to protect themselves is for the glutathione reductase enzyme to hog all the riboflavin so that it says, "I don't have enough of the raw material I need to make this happen, so I'm just going to make myself get way better at using what I do have." That's an adaptation to compensate for not being able to make NADPH is just to get way better at using NADPH to recycle glutathione

Antioxidants 12: 1953 (2023) Hwang C, Sinskey AJ, Lodish HF