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Appetite suppression and weight loss: both drugs suppress ghrelin signaling and reduce appetite through hypothalamic dopaminergic pathways, producing clinically significant weight loss during sustained use

Statistical analysis of the results was performed by one-way analysis of variance, followed by the least significant difference multiple range test or by the Student's t -test for comparisons between two groups of values

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Photomicrographs were obtained using Leica Application Suite analysis software, magnification x440, and quantification was performed on Leica QWin Plus software version 3.0 (Leica Microsystems Inc., Buffalo Grove, IL, USA)