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4 That said, weight, visceral fat, and liver fat all move together under retatrutide, so cleanly isolating a weight-independent component would require a study explicitly designed with that aim (for example, matching weight loss across arms or using clamp-based measures of tissue-specific insulin sensitivity)

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If these technologies mature to the point where a 39-amino acid peptide can be reliably delivered orally with clinically meaningful bioavailability, an actual oral tirzepatide pill becomes possible