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Tenovin-1 is a potent and selective SIRT1 and SIRT2 inhibitor, which can significantly inhibit the enlargement and vacuolation of proximal and distal tubes, thickening of GBM, and lipid droplet accumulation in the HFD-induced DKD rat model and NRK-52E cells treated with HG

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On the other hand, inflammatory conditions may increase drug-protein binding due to acute phase proteins such as -1-acid glycoprotein are produced [23, 32]