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In line with this observation, the pre-administration of DSePA (2 mg/Kg bodyweight) for five consecutive days significantly improved the 30-day survival of mice against the lethal dose (-rays, 10 Gy) of WBI by preventing lipid peroxidation, DNA damage, and apoptosis in the radiosensitive organs like the spleen and small intestine [88, 89]

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The morphological characteristics of necroptosis include cell swelling, nuclear membrane dilation, chromatin condensation, cytoplasmic granulation, and plasma membrane rupture

Up to 45% relapse within one year