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The early divergence of the MACE occurrence curves between the SEMA and placebo groups23 suggests that SEMA may have been directly involved in the SELECT study results through its effects on angiogenesis, reduction of oxidative stress and inflammation, and anti-atherogenic actions derived from GLP-1R activation that promote endothelial function and cell survival7 (Fig
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The safety and pharmacokinetics of oral semaglutide were investigated in two randomised, double-blind, placebo-controlled trials
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