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Insulin and IGF-I action on insulin receptors, IGF-I receptors, and hybrid insulin/IGF-I receptors in vascular smooth muscle cells

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A Dionex Ultimate 3000 high-performance liquid chromatography system and Q Exactive quadrupole orbitrap mass spectrometer (Thermo Fisher) were used to analyze the UBE2m-derived peptides

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Each has somewhat different kinetics with different parameters: UGT3 has simple Michaelis-Menten kinetics

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