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The STEP-1 trial demonstrated mean weight loss of 14.9% with weekly semaglutide.[1] The SURMOUNT-1 trial showed 20.9% with tirzepatide.[2] The SELECT cardiovascular outcomes trial revealed a 20% reduction in major adverse cardiovascular events among non-diabetic patients with obesity.[3] These are not supplements

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PPAR- ligands, such as Wy-14,643, were reported to have an antifibrotic action in the rat thioacetamide (TAA) model of liver cirrhosis [14]