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Plasma samples were processed in strict accordance with the manufacturers instructions

If using a pen, hold the injection button for the full recommended time (usually 5 to 10 seconds) after the dose counter reaches zero

The increased gallstone risk appears to be associated with several factors: Altered bile composition due to rapid fat metabolism Increased cholesterol saturation in bile Changes in gallbladder function during weight loss Patients should be aware that these risks are not unique to weight loss injections any method of rapid weight loss, including very low-calorie diets or bariatric surgery, carries similar gallstone-related risks

Taken together, the involvement of scavenger receptors (such as CD36, SR-B1, SR-BII) of heme uptake during hemolytic crisis warrants further investigation