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However, despite strong evidence that tirzepatide engages the GIPR in competition-binding assays, cell-based experiments using transfected receptors and studies of transgenic mice, there is little functional evidence that tirzepatide directly activates the GIPR in humans as part of its substantial pharmacological effect

This muscle loss can have negative impacts on overall health, strength, and metabolic rate

HbA1c is considered easier to perform despite its lower sensitivity and specificity for diabetes and being unable to diagnose IGT