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[ A recent paper studied primary human monocytes which were differentiated into macrophages and subsequently exposed to different concentrations of uric acid

Summary Keywords inflammatory bowel disease, azathioprine, 6-mercaptopurine, pharmacogenomics, therapeutic drug monitoring Citation Lim SZ and Chua EW (2018) Revisiting the Role of Thiopurines in Inflammatory Bowel Disease Through Pharmacogenomics and Use of Novel Methods for Therapeutic Drug Monitoring

In a 23-week randomized clinical trial in humans, individuals taking AOD-9604 at 1 mg daily had an average of 2.8 kg weight reduction compared to a 0.8 kg weight reduction in those taking a placebo

Schmid C, Bianda T, Zwimpfer C, Zapf J, Wiesli P