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Of note, studies have shown conflicting results in the efficacy of hydroxychloroquine in the treatment of patients with COVID-19 (refs 183,184 )

Evaluation of the remodeling capacity of the extracellular matrix promoted by the pancreatic MMP-2 (matrix metalloproteinase-2) revealed that treatments with the QV formulation or insulin reduced the MMP-2 activity in relation to the untreated diabetic group, and at levels similar to the control group (Fig