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Additionally, ALA has been shown to decrease vascular endothelial damage by lowering levels of AGEs and inflammatory cytokines, both of which contribute to vascular stiffness and impaired perfusion in diabetes [82,97,122]

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Therapeutic strategies targeting mitochondrial OS, known as mitochondrial-targeted antioxidants (MTAs) such as MitoQ, are modulators and promoters of mitochondrial biogenesis (PGC-1 activators), which have shown promise in preclinical HTN models ( Within the therapeutic tools proven effective, Elamipretide (SS-31) is one of the most promising