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The current generation of GLP-1 receptor agonists includes: Semaglutide (weekly subcutaneous injection or oral formulation) Liraglutide (daily subcutaneous injection) Tirzepatide (dual GLP-1/GIP receptor agonist, weekly subcutaneous injection) Each of these GLP-1 agents carries a distinct pharmacological profile, and the optimal choice depends on a patients clinical history, metabolic risk factors, and therapeutic goals a determination best made in consultation with a physician experienced in metabolic and longevity medicine

In a 2025 study of tirzepatide vs

Chronically higher glucose and insulin resistance are linked to worse brain outcomes over time