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Most patients will be trialed initially with Botox injections , given into the internal anal sphincter acting to relax the sphincter and promote healing of the fissure

Many patients experience appetite suppression and mild weight loss even at this starter dose

Most published information currently comes from: While many findings appear promising, additional research is needed to better understand long-term safety, effectiveness, dosing protocols, and potential risks in diverse patient populations

Beyond waste clearance, neurons and glia constantly exchange metabolic signals, with glial cells, particularly astrocytes, playing a critical role in redox homeostasis