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Using the Broad Institutes Connectivity Map dataset, Pickart and colleagues reported that GHK significantly changed the expression of a very large number of human genes (on the order of thousands when a modest expression-change threshold is applied), up-regulating many and down-regulating others in a pattern the authors interpret as a shift toward a healthier, more repair-competent state

doi: 10.1002/jcb.24607 40 Gmez-PuertoMCVerhagenLPBraatAKLamEW-FCofferPJLorenowiczMJ

Yu, S.J

Long-term safety and maintenance of clinical improvement following treatment with anakinra (recombinant human interleukin-1 receptor antagonist) in patients with rheumatoid arthritis: extension phase of a randomized, double-blind, placebo-controlled trial