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In many cases, the underlying cause is not the medication itself, but rather: Rapid weight loss Reduced calorie intake Nutritional deficiencies Physiological stress on the body Hormonal changes associated with weight loss When the body experiences significant change, it may temporarily redirect resources away from non-essential functions such as hair growth

Arch Toxicol 93(9):24912513 Dev P, Pathak A (2024) The current status of cognitive disorders and their diagnosis

Clinical trial evidence from SURMOUNT-1 The landmark SURMOUNT-1 trial, published by Jastreboff and colleagues, provided some of the cleanest data on tirzepatide and hair loss

Sensitivity analyses In order to investigate our hypothesis in a less homogenous but more representative sample, we repeated the analysis in a secondary cohort where competing diagnoses for B use (arrhythmia, ischaemic heart disease and heart failure) were corrected for instead of excluded