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[124] conducted a double-blind, practical trial in which participants were randomly assigned to receive exenatide or placebo to measure changes in carotid plaque volume and composition at 9 and 18 months of treatment, and found no difference in mean change in plaque volume in the exenatide group compared with placebo

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Collectively, these results affirmed that hepsin plays a crucial role in regulating GJ communication, which in turn impacts oxidative stress