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Rosa Caballero, stated that the allergens involved in vitamin B12 reactions is likely to be a hapten, a small molecule that can trigger an immune response when it binds to a larger carrier protein

doi: 10.1161/hq0701.092000

And so he, you know he kind of made the point to me when I spoke to him is that as someone who is very excited about the potential for peptides and thinks that there will be all sorts of potential applications and there will all sorts new drug targets that could potentially really help people and improve their health and well-being

10 L of isotonic saline containing 100 g/mL Nle-YI-(6) aminohexanoic amide as an internal standard is added to each sample on ice