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A vitamin B12 injection introduces the nutrient directly into the bloodstream, bypassing any issues with absorption

When given in the presence of a severe disease picture, a significant prolongation of survival time has been consistently noted

It also makes it easier to rotate stock so that older vials are used first while newer vials remain in deep storage

Additionally, the absence of microbiota, or the presence of broad-spectrum antibiotic-induced dysbiosis, triggered the NOD-like receptor family pyrin domain (PYD)-containing 6 (NLRP6)/Caspase 11 (Casp11) inflammasome-mediated pathway and subsequent loss of iEANs and enteric neuropathy (Muller et al., 2020a)