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For sham controls, animals underwent laminectomy without subsequent injury
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Thyroid follicular cells themselves can aberrantly express MHC class II and co-stimulatory molecules (B7.1/CD80), enabling them to act as non-professional antigen-presenting cells (APCs) and amplify the autoimmune cascade
A significant number of free radicals are generated during Phase 1, which can result in liver damage if adequate antioxidants (especially glutathione) are not available to quench them
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