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1, Extended Data Tables 16 and Supplementary Section 2), with a clear trend of growing relevant literature over the past few years as the use of these medications becomes more widespread and their indications expand far beyond the initial intentions of the manufacturers 223

The Big Picture Despite the potential for side effects like gastroparesis and SIBO, semaglutide offers huge benefits

Semaglutide-related fatigue primarily occurs due to dramatically reduced calorie intake as appetite suppresses, rapid weight loss causing metabolic adjustments, possible dehydration from eating and drinking less, inadequate protein consumption leading to muscle loss, blood sugar changes particularly in people with diabetes, and possible sleep disruptions