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In published Phase 2 clinical studies, retatrutide was evaluated using once-weekly dosing schedules , with doses escalating up to 12 mg over a 48-week treatment period

But tirzepatides dual action on GLP-1 and GIP receptors gives it a broader metabolic impact

After one week of CARNITOR therapy (3 doses), all patients had trough concentrations between 54 and 180 mol/L (normal 40-50 mol/L) and concentrations remained relatively stable or increased over the course of the study

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