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Targeting both types of receptors enhances tirzepatides effects on digestion and blood sugar, potentially explaining why it can be more effective than semaglutide

Significantly, the expression of RAGE is markedly upregulated under various pathological circumstances, especially in atherosclerosis, diabetes mellitus, CVD, RA, Alzheimer's disease (AD), and immunerelated disorders [229,230,231,232,233]

The synergistic effects of these agents on monoaminergic modulation, neurotrophic signaling, inflammatory responses, oxidative stress management, and stress-response mechanisms provide a compelling mechanistic foundation for their therapeutic significance in the treatment of depressive disorders