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Advanced sleep-wake phase disorder is partially due to the physiologic advance that occurs with aging together with the weakening of circadian rhythms observed with aging

While obesity rates have remained stable over the past decade, rates of severe obesity have increased, from 7.7% to 9.7%

(Rubino et al., JAMA, 2021 PubMed: 33755728) STEP 5 Trial (2022) At 104 weeks (two years), semaglutide produced mean weight loss of 15.2% versus 2.6% with placebo, demonstrating sustained long-term efficacy