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Findings from recently completed trials indicate that a GLP-1 RA-induced increase in HR, regardless of magnitude, does not present an increased cardiovascular risk for subjects with T2DM, although a pronounced increase in HR may be associated with adverse clinical outcomes in those with advanced heart failure

The peptide's effects on hormonal systems, particularly growth hormone and cortisol, may have implications for certain conditions

Bradley EH, Herrin J, Wang Y, McNamara RL, Radford MJ, Magid DJ, Canto JG, Blaney M, Krumholz HM

Aversion to surgery If your religion or culture is against surgical procedures, other, less effective options are available