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While some people notice some of the effects of the medication, such as fewer cravings between meals, within a few weeks, the weight loss results of the treatment often take a few months to become apparent

(146) observed significant blood-to-brain influx for non-acylated GLP-1 mimetics like exendin-4 and lixisenatide, whereas acylated GLP-1 analogues such as liraglutide and semaglutide showed minimal blood-brain barrier penetration in mice