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(1) FSP1/AIFM2: FSP1 was originally classified as a caspase-independent apoptosis-inducing protein, on the basis of its sequence similarity to apoptosis-inducing factor 1 (AIFM1), and was annotated as a flavoprotein with NAD(P)H oxidase activity 38

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Antitumor effects of MTX are, in part, attributed to apoptosis induction in many cancers (Pawlak et al., 2017

For a patient whose entire complaint can be summarized as I cannot sleep and therefore everything else suffers, addressing the sleep deficiency directly before layering in energy or anabolic therapies is the more precise clinical decision