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These coordinated responses promote TFEB nuclear translocation, enhance lysosomal and autophagic gene expression more effectively than rapamycin and attenuate phosphorylated tau, total tau and p62 accumulation, highlighting zincs therapeutic potential in restoring lysosomal proteolysis and autophagy 103,167

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The oral delivery format may have different bioavailability compared to injectable protocols, and dosing equivalency between administration routes is not definitively established through comparative pharmacokinetic studies