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doi: 10.3389/fnut.2025.1541054 Received 06 December 2024 Accepted 20 March 2025 Published 09 April 2025 Volume 12 - 2025 Edited by Peng An, China Agricultural University, China Reviewed by Naseem Akhtar Qureshi, Al-Falah University, India Denis Fedorinov, Russian Medical Academy of Postgraduate Education, Russia Updates Copyright 2025 Overton, Emelyanova and Bunik

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Polyphenols may be classified into different groups as a function of the number of phenol rings that they contain and on the basis of structural elements that bind these rings [51]

One possible explanation for such a response is that inhibition of mTORC1 and activation of GCN2 collectively suppresses global translation to conserve nutrients, while selective translation of mRNA such as ATF4 (mediated by increased p-eIF2) activates the expression of AARE genes to mitigate cellular stress