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While the study establishes a compelling systemic role for SLC25A45 in fuel switching, important questions remain regarding the tissue-specific contributions of this pathway and how carnitine biosynthesis and utilization are differentially regulated across dietary, disease, and sexually dimorphic contexts

But lupus patients need to view tirzepatide side effects through a different lens than the general population because some effects that are merely annoying for healthy individuals could signal something more significant in SLE

In the Triumph-3 trial, participants lost up to 22.6% of their body weight over the same period

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