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If you are on semaglutide and not losing weight, there can be a number of reasons, including: 1

Comparisons Of Efficacy And Safety Of Oral Semaglutide And Injectable Liraglutide Or Semaglutide To determine efficacy and safety of oral semaglutide as monotherapy, the 26-week, phase 3, double-blinded, placebo-controlled RCT (PIONEER-1) primarily aimed to demonstrate glycemic superiority of once-daily oral semaglutide against placebo in 703 T2D adults with mean age of 5511 years, BMI of 31.86.6 kg/m 2 , baseline HbA1c of 8.00.7% (638 mmol/mol), and diabetes duration of 3.5 years

Specifically, Karayiannides et al

Consider starting a new vial if you notice diminished effects