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In specific embodiments, osmolarity/osmolality of the present formulations or compositions is adjusted, for example, by the use of appropriate salt concentrations (e.g., concentration of potassium salts) or the use of tonicity agents which renders the formulations or compositions endolymph-compatible and/or perilymph-compatible (i.e

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Moreover, other lines of research indicate that acyl-carnitine supplementation can be considered as a potential therapeutic strategy across several neuropsychiatric disorders (i.e., schizophrenia, autism, depression, etc.) with unique neuroprotective effects including anti-inflammatory and antioxidant benefits 27,43

The resulting docking poses obtained from Autodock Vina applying our settings resembled almost perfectly the tyrosine pose found in the crystal structure of the Bm TYR-tyrosine complex (PDB entry 4P6R) 68 indicating that the defined settings were suitable