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The hydroxyl moiety combines with the peroxyl radical (ROO ) via a coordinated pathway from the phenol to the radical, resulting in a transition state with an H-O bond containing one electron [204]

Meanwhile, ATP detection assays confirmed that the ATP level in GGCT-knockdown cells was significantly reduced and rescued in sodium pyruvate or JX06 treatment groups (Fig

Resveratrol, a natural polyphenol, exerts anti-eryptotic effects by suppressing ROS-dependent signaling pathways that regulate Ca 2+ mobilization and PS externalization, while also reducing inflammation-associated oxidative stress in CKD, thus decreasing erythrocyte susceptibility to eryptosis (Qadri et al., 2009)