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Regarding oxidative stress, bilirubin directly scavenges reactive species such as ROS and NO, protects mitochondrial electron transport chain function, and maintains stable energy metabolism in DA neurons ( Secondly, this study proposes a forward-looking perspective: bilirubin's protective effects may extend to the developmental stage of DA neurons during embryogenesis

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The recent identification of hybrid ketoacid dehydrogenase complexes between the E1 subunit of OADHc (DHTKD1) and the OGDHc 40 indicates that more complex crosstalk exists between ketoacid dehydrogenases, and we speculate that these hybrid complexes may be more susceptible to acyl-lipoyl adduct formation

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