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Cell imaging studies Briefly, after incubating 4T1 cells in a confocal culture dish for 24 h, the culture medium is replaced with a culture medium solution containing the desired concentration of the compound

This clued investigators in to the importance of the second phase of the detoxification process and raised the question of whether the balance between the first two phases might determine the chemicals toxicity and carcinogenicity

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These chemical or physical modifications of small molecule ferroptosis modulators improve their bioavailability and targeting, and significantly increase their clinical application potential