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GLP-1, an originally identified natural prototype, is synthesized and secreted by intestinal enteroendocrine L-cells and certain neurons within the nucleus of the solitary tract in the brainstem [2]

Pharmacological effects of GLP-1R agonism on energy homeostasis Despite controversial findings over the role of the endogenous GLP-1 system in maintaining energy homeostasis, consistent findings demonstrate that pharmacological administration of GLP-1R agonists suppresses body weight across a number of species

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