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[PubMed: 8786016] (Among 328 patients with diabetic peripheral neuropathy treated with ALA [100, 600, or 1200 mg] or placebo intravenously 4 to 5 days per week for 3 weeks, total neuropathy symptom scores improved by 43%, 63% and 58% with ALA vs 38% with placebo, while adverse events were similar with the lower doses as with placebo [14% and 18% vs 21%] but higher with the highest dose [33%]

Review of a fatal combination

To minimize TMAO production, it is vital to adhere to the divided dosing strategy, keeping single doses under 1,000 mg to ensure maximum small intestinal absorption and minimal spillover into the large intestine

Lactobacillus rhamnosus GG induces STING-dependent IL-10 in intestinal monocytes and alleviates inflammatory colitis in mice