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A big difference between semaglutide and tirzepatide is that semaglutide mimics the action of one hormone GLP-1 while tirzepatide mimics the action of two, a GLP-1 and something called a GIP, or glucose-dependent insulinotropic polypeptide
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17/117 (14.5%) not using semaglutide (Wegovy) with retained gastric contents on EGD ( p = 0.426)
These obese mice also showed activation of microglia and astrocytes and significant immunoreactivity of neuroinflammatory and apoptosis markers, such as TNF-, COX-2, and Caspase-3, in addition to lower expression of neurogenesis and synaptic plasticity markers, such as NeuN, KI-67, CREB-p, and BDNF
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