MIN6 cells were perfused with HBSS containing 10 nM GLP-1, and cytosolic Ca 2+ concentrations were measured using a 2- wavelength excitation method (340/380) for 10 min (solid line of left panel)
Em pessoas com diabetes tipo 2, a produo de GLP-1 normalmente no est alterada (embora isso possa ocorrer), mas as clulas do pncreas apresentam uma resposta reduzida ao do hormnio
Because of this, they function alongside each other instead of clashing
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