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These processes converge on synaptic dysfunction and reduced synaptic plasticity, which may underlie both the persistence of depressive symptoms, and the high rates of treatment resistance observed in LLD

(4) Measure development and reporting tools

It is intended for use in clinical settings where oral administration is not feasible or where higher plasma concentrations are desired, such as in cases of severe deficiency, certain infections, or as adjunctive therapy in specific medical protocols

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