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In eukaryotes and some prokaryotes, the isoprene carbon units are obtained from the mevalonate pathway to make the CoQ side chain (Fernndez-del-Ro and Clarke, 2021), or the deoxyglucose-5-phosphate pathway in plants, prokaryotes, and some protozoa (Wang and Hekimi, 2016)

Lancet 394, 3950

Fer-1 faces bioavailability and metabolic stability obstacles, with a notably short plasma half-life and imperfect penetration through the BBB, limiting its use in neurodegenerative conditions [99, 228, 229]